Drug Development in Endometriosis and Adenomyosis: It Takes More Than Just Good Science
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 9, S. 1318-1329
ISSN: 1933-7205
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In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 9, S. 1318-1329
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 30, Heft 3, S. 928-951
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 11, S. 1540-1548
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 7, S. 1024-1036
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 3, S. 329-340
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 24, Heft 6, S. 829-835
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 23, Heft 9, S. 1217-1224
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 23, Heft 8, S. 1044-1052
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 17, Heft 11, S. 995-1005
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 17, Heft 10, S. 904-912
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 14, Heft 4, S. 374-382
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 29, Heft 4, S. 1170-1187
ISSN: 1933-7205
AbstractThe development of more efficacious, non-hormonal therapeutics for endometriosis is still an unmet medical need begging to be fulfilled. Growing evidence indicates that endometriotic lesions are wounds undergoing repeated tissue injury and repair, and, as such, platelets play an important role in lesional progression. Tetramethylpyrazine (TMP), a compound derived from a herb that has been used for thousands of years to combat "blood stasis" in traditional Chinese medicine, is a prescription drug in China for the treatment of cerebrovascular disorders. We tested the hypothesis that TMP can decelerate lesional progression through arresting epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), and fibrogenesis. We found in our in vitro experiments that TMP treatment suppresses platelet-induced EMT, FMT, cellular contractility, and collagen production in a concentration-dependent manner. We also showed that in a mouse model of endometriosis, treatment with TMP significantly reduced lesion weight and the extent of lesional fibrosis and improved hyperalgesia, mostly likely through the reduction of lesional aggregation of platelets and the lesional expression of markers of EMT, FMT, and fibrogenesis. In light of our results and in view of its excellent safety profiles, TMP appears to be a promising drug candidate for treating endometriosis.
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 27, Heft 7, S. 1423-1435
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 26, Heft 5, S. 697-708
ISSN: 1933-7205
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 25, Heft 4, S. 498-514
ISSN: 1933-7205